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Article

Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster.

Genetics - 1 Jan 2009

Matthews Krista A, Kunte Amit S, Tambe-Ebot Edward, Rawson Robert B

Abstract excerpt

Sterol regulatory element binding protein (SREBP) is a major transcriptional regulator of lipid metabolism. Nuclear Drosophila SREBP (dSREBP) is essential for larval development in Drosophila melanogaster but dispensable in adults. dSREBP(-) larvae die at second instar owing to loss of dSREBP-mediated transcription but survive to adulthood when fed fatty acids. Activation of SREBP requires two separate cleavages....

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Identifiers

PMID: 19015545
DOI: 10.1534/genetics.108.093450
PMCID: PMC2621160

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