Article
The SREBP pathway in Drosophila: regulation by palmitate, not sterols.
Developmental cell - 1 Feb 2002
Seegmiller Adam C, Dobrosotskaya Irina, Goldstein Joseph L, Ho Y K, Brown Michael S, Rawson Robert B
Abstract excerpt
In mammals, synthesis of cholesterol and unsaturated fatty acids is controlled by SREBPs, a family of membrane-bound transcription factors. Here, we show that the Drosophila genome encodes all components of the SREBP pathway, including a single SREBP (dSREBP), SREBP cleavage-activating protein (dSCAP), and the two proteases that process SREBP at sites 1 and 2 to release the nuclear fragment. In cultured...
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