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Article

Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation.

PLoS genetics - 1 Apr 2011

Tian Yuan, Bi Junfeng, Shui Guanghou, Liu Zhonghua, Xiang Yanhui, Liu Yuan, Wenk Markus R, Yang Hongyuan, Huang Xun

Abstract excerpt

Obesity is characterized by accumulation of excess body fat, while lipodystrophy is characterized by loss or absence of body fat. Despite their opposite phenotypes, these two conditions both cause ectopic lipid storage in non-adipose tissues, leading to lipotoxicity, which has health-threatening consequences. The exact mechanisms underlying ectopic lipid storage remain elusive. Here we report the analysis of a...

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Identifiers

PMID: 21533227
DOI: 10.1371/journal.pgen.1001364
PMCID: PMC3077376

Genes

BSCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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