Article
Mismatches outside exons 2 and 3 do not alter the peptide motif of the allele group B*44:02P.
Human immunology - 1 Nov 2011
Bade-Doeding Christina, Cano Pedro, Huyton Trevor, Badrinath Soumya, Eiz-Vesper Britta, Hiller Oliver, Blasczyk Rainer
Abstract excerpt
Sequence variations outside exons 2 and 3 do not appear to affect the function of human leukocyte antigen (HLA) class I alleles. HLA-B*44:02:01:01 and -B*44:27 are considered functionally identical because they differ by a single amino acid substitution of Val > Ala at position 199, which is located in the α3 domain. To validate that HLA-B*44:02:01:01 and -B*44:27 represent functionally identical alleles that...
Topics
- Amino Acid Motifs
- B-Lymphocytes
- Cell Line, Tumor
- Chromatography, Affinity
- Donor Selection
- Exons
- HLA Antigens
- HLA-B Antigens
- HLA-B44 Antigen
- Hematopoietic Stem Cell Transplantation
- Histocompatibility
- Humans
- Mutation
- Peptide Fragments