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Article

Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability.

The Journal of biological chemistry - 3 Dec 2010

Sheu Jim Jinn-Chyuan, Guan Bin, Choi Jung-Hye, Lin Athena, Lee Chia-Huei, Hsiao Yi-Ting, Wang Tian-Li, Tsai Fuu-Jen, Shih Ie-Ming

Abstract excerpt

Rsf-1 (HBXAP) has been reported as an amplified gene in human cancer, including the highly aggressive ovarian serous carcinoma. Rsf-1 protein interacts with SNF2H to form an ISWI chromatin remodeling complex, RSF. In this study, we investigated the functional role of Rsf-1 by observing phenotypes after expressing it in nontransformed cells. Acute expression of Rsf-1 resulted in DNA damage as evidenced by DNA...

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PMID: 20923775
DOI: 10.1074/jbc.M110.138735
PMCID: PMC2992260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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