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Functional Analysis of 11q13.5 Amplicon Identifies <i>Rsf-1</i> (<i>HBXAP</i>) as a Gene Involved in Paclitaxel Resistance in Ovarian Cancer

4 Feb 2009

Abstract excerpt

The chromosome 11q13.5 locus is frequently amplified in several types of human cancer. We have previously shown that 11q13.5 amplification was associated with significantly shorter overall survival in ovarian cancer patients, but the molecular mechanisms of how amplification of this locus contributes to disease aggressiveness remain unclear. Because ovarian cancer mortality is primarily related to resistance of...

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PMID: 19190325
DOI: 10.1158/0008-5472.can-08-3602

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