Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair

2 Apr 2018

Abstract excerpt

Significance DNA is frequently damaged by both endogenous and exogenous factors. In response to DNA damage, cells activate checkpoints to arrest cell cycle progression, allowing sufficient time for DNA repair. Defects in DNA repair cause many diseases including cancers. The E2F transcription factors are key players in cell cycle progression and are negatively regulated by the tumor suppressor protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Plant Molecular Biology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29610335
DOI: 10.1073/pnas.1720094115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repairPMID 29610335Read ↗

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joiningSemantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

E2F-7 couples DNA damage-dependent transcription with the DNA repair process.Semantic proximity Read ↗

E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factorsSemantic proximity Read ↗

Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targetsSemantic proximity Read ↗

SWI/SNF Factors Required for Cellular Resistance to DNA Damage Include ARID1A and ARID1B and Show Interdependent Protein StabilitySemantic proximity Read ↗

The roles of mutated SWI/SNF complexes in the initiation and development of hepatocellular carcinoma and its regulatory effect on the immune system: A review.Semantic proximity Read ↗

DNA repair choice defines a common pathway for recruitment of chromatin regulators.Semantic proximity Read ↗

Requirement of Nse1, a subunit of the Smc5-Smc6 complex, for Rad52-dependent postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex.Semantic proximity Read ↗

βTrCP is involved in the localization of the MRN complex on chromatin to enhance DNA damage repairSemantic proximity Read ↗

The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.