Article
Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism.
eLife - 23 Dec 2020
Orlando Krystal Ann, Douglas Amber K, Abudu Aierken, Wang Yemin, Tessier-Cloutier Basile, Su Weiping, Peters Alec, Sherman Larry S, Moore Rayvon, Nguyen Vinh, Negri Gian Luca, Colborne Shane, Morin Gregg B, Kommoss Friedrich, Lang Jessica D, Hendricks William Pd, Raupach Elizabeth A, Pirrotte Patrick, Huntsman David G, Trent Jeffrey M, Parker Joel S, Raab Jesse R, Weissman Bernard E
Abstract excerpt
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in SMARCA4 (BRG1), one of the two mutually exclusive ATPases of the SWI/SNF chromatin remodeling complex. To address the role that BRG1 loss plays in SCCOHT tumorigenesis, we performed integrative multi-omic analyses in SCCOHT cell lines +/- BRG1 reexpression....
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