Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells.

Stem cell reports - 11 Feb 2014

Miyagi Satoru, Koide Shuhei, Saraya Atsunori, Wendt George R, Oshima Motohiko, Konuma Takaaki, Yamazaki Satoshi, Mochizuki-Kashio Makiko, Nakajima-Takagi Yaeko, Wang Changshan, Chiba Tetsuhiro, Kitabayashi Issay, Nakauchi Hiromitsu, Iwama Atsushi

Abstract excerpt

TIF1β is a transcriptional corepressor that recruits repressive chromatin modifiers to target genes. Its biological function and physiological targets in somatic stem cells remain largely unknown. Here, we show that TIF1β is essential for the maintenance of hematopoietic stem cells (HSCs). Deletion of Tif1b in mice induced active cycling and apoptosis of HSCs and promoted egression of HSCs from the bone marrow,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Bone Marrow

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromobox Protein Homolog 5

Share to Chromosomal Proteins, Non-Histone

Share to Gene Knockout Techniques

Share to Gene Targeting

Share to Hematopoiesis

Source

Open in PubMed Open full text

Identifiers

PMID: 24527388
DOI: 10.1016/j.stemcr.2013.12.008
PMCID: PMC3923190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells.PMID 24527388Read ↗

Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells.Semantic proximity Read ↗

Mouse HP1γ regulates TRF1 expression and telomere stabilitySemantic proximity Read ↗

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancersSemantic proximity Read ↗

Heterochromatin protein 1 (HP1) is intrinsically required for post-transcriptional regulation of <i>Drosophila</i> Germline Stem Cell (GSC) maintenanceSemantic proximity Read ↗

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genesSemantic proximity Read ↗

IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenanceSemantic proximity Read ↗

Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid LeukemiaSemantic proximity Read ↗

The role of telomere binding molecules for normal and abnormal hematopoiesis.Semantic proximity Read ↗

Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouseSemantic proximity Read ↗

Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells.Semantic proximity Read ↗

Hematopoietic stem cells retain functional potential and molecular identity in hibernation culturesSemantic proximity Read ↗

HP1α depletion and TGFβ activation exert antagonistic effects on 3D genome organizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.