Article
Analysis of the common vasoactive intestinal peptide receptor 1 polymorphism in gallstone patients.
Journal of gastrointestinal and liver diseases : JGLD - 1 Sept 2010
Krawczyk Marcin, Rusticeanu Monica, Grünhage Frank, Mahler Miriam, Portincasa Piero, Acalovschi Monica, Lammert Frank
Abstract excerpt
BACKGROUND AND AIM: Cholesterol gallstone disease is caused by both genetic and environmental factors (e.g., deranged motility of the gallbladder wall). Recently, a single nucleotide polymorphism (SNP) of the vasoactive intestinal peptide receptor 1 (VIPR1) gene has been linked to late onset of achalasia, a lower esophagus dysmotility disorder. As VIPR1 is expressed in the gallbladder wall as well, and patients...
Topics
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Body Mass Index
- Case-Control Studies
- Chi-Square Distribution
- Female
- Gallstones
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Lod Score