Article
The common adiponutrin variant p.I148M does not confer gallstone risk but affects fasting glucose and triglyceride levels.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Jun 2011
Krawczyk M, Gruenhage F, Mahler M, Tirziu S, Acalovschi M, Lammert F
Abstract excerpt
Recently the common adiponutrin (PNPLA3) polymorphism p.I148M has been identified as a genetic determinant of severe forms of non-alcoholic fatty liver disease and alcoholic liver disease. Additionally, insulin resistance - linked to the development of non-alcoholic steatohepatitis - increases the risk of developing gallstones. Here we assessed whether the PNPLA3 p.I148M (c.444 C-G) polymorphism affects glucose...
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