Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer.

Abstract excerpt

BACKGROUND AND AIM: Gallbladder carcinoma (GBC) usually arises in the background of gallstone disease which may be causatively related to decreased gallbladder contractility. Cholecystokinin receptor A (CCK-AR) mediates signals resulting in gallbladder contraction. Deteriorating gallbladder contraction promotes gallstone formation. A common genetic polymorphism of CCK-AR may be causatively associated with the...

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