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Article

From lymphocytes to sharks: V(D)J recombinase moves to the germline.

Genome biology - 1 Jan 2000

Roth D B

Abstract excerpt

The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci.

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Share to DNA Nucleotidyltransferases
Share to Genetic Variation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Lymphocytes

Share to Recombination, Genetic

Share to Sharks

Share to VDJ Recombinases

Source

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Identifiers

PMID: 11178236
DOI: 10.1186/gb-2000-1-2-reviews1014
PMCID: PMC138851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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