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Article

Mitochondrial complex II participates in normoxic and hypoxic regulation of α-keto acids in the murine heart.

Journal of molecular and cellular cardiology - 1 Dec 2010

Mühling Jörg, Tiefenbach Martina, López-Barneo José, Piruat José I, García-Flores Paula, Pfeil Uwe, Gries Barbara, Mühlfeld Christian, Weigand Markus A, Kummer Wolfgang, Weissmann Norbert, Paddenberg Renate

Abstract excerpt

α-Keto acids (α-KAs) are not just metabolic intermediates but are also powerful modulators of different cellular pathways. Here, we tested the hypothesis that α-KA concentrations are regulated by complex II (succinate dehydrogenase=SDH), which represents an intersection between the mitochondrial respiratory chain for which an important function in cardiopulmonary oxygen sensing has been demonstrated, and the...

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Source

Identifiers

PMID: 20920510
DOI: 10.1016/j.yjmcc.2010.09.023

Genes

SDHD
SDHA
SDHB
SDHC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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