Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial complex II participates in normoxic and hypoxic regulation of α-keto acids in the murine heart.

Journal of molecular and cellular cardiology - 1 Dec 2010

Mühling Jörg, Tiefenbach Martina, López-Barneo José, Piruat José I, García-Flores Paula, Pfeil Uwe, Gries Barbara, Mühlfeld Christian, Weigand Markus A, Kummer Wolfgang, Weissmann Norbert, Paddenberg Renate

Abstract excerpt

α-Keto acids (α-KAs) are not just metabolic intermediates but are also powerful modulators of different cellular pathways. Here, we tested the hypothesis that α-KA concentrations are regulated by complex II (succinate dehydrogenase=SDH), which represents an intersection between the mitochondrial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomegaly
Share to Electron Transport Complex II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Ventricles

Share to Hypoxia

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Myocytes, Cardiac

Share to Protein Stability

Share to Succinate Dehydrogenase

Source

Identifiers

PMID: 20920510
DOI: 10.1016/j.yjmcc.2010.09.023

Genes

SDHD
SDHA
SDHB
SDHC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20920510-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial complex II participates in normoxic and hypoxic regulation of α-keto acids in the murine heart.PMID 20920510Read ↗

Mild hypoxia in vivo regulates cardioprotective SUR2A: A role for Akt and LDH.Semantic proximity Read ↗

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromesSemantic proximity Read ↗

Hepatic Ketogenesis Attenuates Cardiac Hypertrophy via Metabolic ReprogrammingSemantic proximity Read ↗

Succinyl-CoA-based energy metabolism dysfunctions in chronic heart failureSemantic proximity Read ↗

Comparative Analysis of Right Ventricular Metabolic Reprogramming in Pre-clinical Rat Models of Severe Pulmonary Hypertension-induced Right Ventricular FailureSemantic proximity Read ↗

Reducing Reactive Lipids Improves Cardiac Metabolic and Diastolic Function in Pulmonary Hypertension ModelsSemantic proximity Read ↗

Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.Semantic proximity Read ↗

Myocardial Interstitial Matrix as Novel Target for Succinic Acid Treatment Strategies during Experimental Hypobaric HypoxiaSemantic proximity Read ↗

Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1s/sα2s/s Mouse Model of High Affinity for Cardiotonic Steroids.Semantic proximity Read ↗

The Heart has Intrinsic Ketogenic Capacity that is Facultatively Upregulated in Heart Failure with Preserved Ejection FractionSemantic proximity Read ↗

Partial loss of succinate dehydrogenase reduces high red cell distribution width and promotes healthy survival in chronically hypoxic miceSemantic proximity Read ↗

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.