Article
Mild hypoxia in vivo regulates cardioprotective SUR2A: A role for Akt and LDH.
Biochimica et biophysica acta - 1 May 2015
Mohammed Abdul Khaja Shameem, Jovanović Sofija, Du Qingyou, Sukhodub Andriy, Jovanović Aleksandar
Abstract excerpt
High-altitude residents have lower mortality rates for ischaemic heart disease and this is ascribed to cardiac gene remodelling by chronic hypoxia. SUR2A is a cardioprotective ABC protein serving as a subunit of sarcolemmal ATP-sensitive K(+) channels. The purpose of this study was to determine whether SUR2A is regulated by mild hypoxia in vivo and to elucidate the underlying mechanism. Mice were exposed to...
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