Article
The rate of the molecular clock and the cost of gratuitous protein synthesis.
Genome biology - 1 Jan 2010
Plata Germán, Gottesman Max E, Vitkup Dennis
Abstract excerpt
BACKGROUND: The nature of the protein molecular clock, the protein-specific rate of amino acid substitutions, is among the central questions of molecular evolution. Protein expression level is the dominant determinant of the clock rate in a number of organisms. It has been suggested that highly expressed proteins evolve slowly in all species mainly to maintain robustness to translation errors that generate toxic...
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