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Article

A model of proteostatic energy cost and its use in analysis of proteome trends and sequence evolution.

PloS one - 1 Jan 2014

Kepp Kasper P, Dasmeh Pouria

Abstract excerpt

A model of proteome-associated chemical energetic costs of cells is derived from protein-turnover kinetics and protein folding. Minimization of the proteostatic maintenance cost can explain a range of trends of proteomes and combines both protein function, stability, size, proteostatic cost, temperature, resource availability, and turnover rates in one simple framework. We then explore the ansatz that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24587382
DOI: 10.1371/journal.pone.0090504
PMCID: PMC3938754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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