Article
A Comparison of the Costs and Benefits of Bacterial Gene Expression.
PloS one - 1 Jan 2016
Price Morgan N, Wetmore Kelly M, Deutschbauer Adam M, Arkin Adam P
Abstract excerpt
To study how a bacterium allocates its resources, we compared the costs and benefits of most (86%) of the proteins in Escherichia coli K-12 during growth in minimal glucose medium. The cost or investment in each protein was estimated from ribosomal profiling data, and the benefit of each protein was measured by assaying a library of transposon mutants. We found that proteins that are important for fitness are...
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