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Article

Protein biophysics explains why highly abundant proteins evolve slowly.

Cell reports - 30 Aug 2012

Serohijos Adrian W R, Rimas Zilvinas, Shakhnovich Eugene I

Abstract excerpt

The consistent observation across all kingdoms of life that highly abundant proteins evolve slowly demonstrates that cellular abundance is a key determinant of protein evolutionary rate. However, other empirical findings, such as the broad distribution of evolutionary rates, suggest that additional variables determine the rate of protein evolution. Here, we report that under the global selection against the...

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Identifiers

PMID: 22938865
DOI: 10.1016/j.celrep.2012.06.022
PMCID: PMC3533372

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