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Article

Interdependence of translation, transcription and mRNA degradation in the lacZ gene.

Journal of molecular biology - 5 Aug 1992

Yarchuk O, Jacques N, Guillerez J, Dreyfus M

Abstract excerpt

We have constructed a collection of Escherichia coli strains which differ by point mutations in the ribosome binding site (RBS) that drives the translation of the lacZ gene. These mutations affect the Shine-Dalgarno sequence or the initiation codon, or create secondary structures that sequester these elements, and result in a 200-fold variation in beta-galactosidase expression. Surprisingly, these variations of...

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Identifiers

PMID: 1507217
DOI: 10.1016/0022-2836(92)90617-s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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