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Article

Interdependence of translation, transcription and mRNA degradation in the lacZ gene.

Journal of molecular biology - 5 Aug 1992

Yarchuk O, Jacques N, Guillerez J, Dreyfus M

Abstract excerpt

We have constructed a collection of Escherichia coli strains which differ by point mutations in the ribosome binding site (RBS) that drives the translation of the lacZ gene. These mutations affect the Shine-Dalgarno sequence or the initiation codon, or create secondary structures that sequester these elements, and result in a 200-fold variation in beta-galactosidase expression. Surprisingly, these variations of...

Topics

Base Sequence
Chromosomes, Bacterial
Escherichia coli
Genes, Bacterial
Genotype
Introns
Molecular Sequence Data
Nucleic Acid Conformation
Oligodeoxyribonucleotides
Protein Biosynthesis
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Restriction Mapping

Ribosomes

Transcription, Genetic

beta-Galactosidase

Source

Identifiers

PMID: 1507217
DOI: 10.1016/0022-2836(92)90617-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1507217-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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