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Article

Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences

29 Sept 2010

Abstract excerpt

BACKGROUND: The Ras association domain family (RASSF) encodes for distinct tumor suppressors and several members are frequently silenced in human cancer. In our study, we analyzed the role of RASSF2, RASSF3, RASSF4, RASSF5A, RASSF5C and RASSF6 and the effectors MST1, MST2 and WW45 in thyroid carcinogenesis. RESULTS: Frequent methylation of the RASSF2 and RASSF5A CpG island promoters in thyroid tumors was...

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PMID: 20920251
DOI: 10.1186/1476-4598-9-264

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