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Article

Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma

24 Feb 2008

Abstract excerpt

Genetic and epigenetic alterations in tumor-suppressor genes play important roles in human neoplasia. Ras signaling is often activated in oral squamous cell carcinoma (OSCC), although Ras mutations are rarely detected in Japanese OSCC patients, and the mechanisms underlying the gene's activation remain unclear. Here, we examined the expression of Ras association family (RASSF) genes in a panel of OSCC cell lines...

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PMID: 18294275
DOI: 10.1111/j.1349-7006.2008.00769.x

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