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Article

RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors.

Laboratory investigation; a journal of technical methods and pathology - 1 Sept 2005

Nakamura Nobuki, Carney J Aidan, Jin Long, Kajita Sabine, Pallares Judit, Zhang Heyu, Qian Xiang, Sebo Thomas J, Erickson Lori A, Lloyd Ricardo V

Abstract excerpt

We analyzed RASSF1A and NORE1A methylation and BRAF mutation in 89 thyroid tumors, 42 non-neoplastic thyroid tissues and three thyroid tumor cell lines using polymerase chain reaction (PCR), methylation-specific PCR, Western blotting and DNA sequencing in order to study thyroid tumor pathogenesis and progression. RASSF1A promoter methylation was present in all three thyroid cell lines and in 27/78 (35%) of benign...

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Source

Identifiers

PMID: 15980887
DOI: 10.1038/labinvest.3700306

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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