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Article

Correlation between BRAF mutation and promoter methylation of TIMP3, RARβ2 and RASSF1A in thyroid cancer.

Epigenetics - 1 Jul 2012

Brait Mariana, Loyo Myriam, Rosenbaum Eli, Ostrow Kimberly L, Markova Alina, Papagerakis Silvana, Zahurak Marianna, Goodman Steven M, Zeiger Martha, Sidransky David, Umbricht Christopher B, Hoque Mohammad O

Abstract excerpt

Our aim was to comprehensively analyze promoter hypermethylation of a panel of novel and known methylation markers for thyroid neoplasms and to establish their relationship with BRAF mutation and clinicopathologic parameters of thyroid cancer. A cohort of thyroid tumors, consisting of 44 cancers and 44 benign thyroid lesions, as well as 15 samples of adjacent normal thyroid tissue, was evaluated for BRAF mutation...

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Topics

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Share to DNA Methylation
Share to Early Detection of Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Proto-Oncogene Proteins B-raf

Share to Receptors, Retinoic Acid

Share to Thyroid Neoplasms

Share to Tissue Inhibitor of Metalloproteinase-3

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22694820
DOI: 10.4161/epi.20524
PMCID: PMC3414391

Genes

BRAF
TIMP3
CTNNB1
DCC
ATM
CALCA
GSTP1
NISCH
PAK3
THBS1
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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