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Article

Frequent silencing of RASSF1A via promoter methylation in follicular thyroid hyperplasia: a potential early epigenetic susceptibility event in thyroid carcinogenesis.

JAMA surgery - 1 Nov 2014

Brown Taylor C, Juhlin C Christofer, Healy James M, Prasad Manju L, Korah Reju, Carling Tobias

Abstract excerpt

IMPORTANCE: Follicular thyroid hyperplasia (FTH) refers to enlargement of the thyroid gland due to cellular hyperplasia. It is frequently encountered in clinical practice in nontoxic uninodular or multinodular goiter. The genetic and epigenetic events associated with the origin and malignant potential of FTH are poorly understood. OBJECTIVE: To analyze FTH samples for known recurrent genetic and epigenetic driver...

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Share to Adenocarcinoma, Follicular
Share to GTP Phosphohydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Silencer Elements, Transcriptional

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Source

Identifiers

PMID: 25229773
DOI: 10.1001/jamasurg.2014.1694

Genes

BRAF
NRAS
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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