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Article

Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis.

Cancer research - 1 Mar 2004

Xing Mingzhao, Cohen Yoram, Mambo Elizabeth, Tallini Giovanni, Udelsman Robert, Ladenson Paul W, Sidransky David

Abstract excerpt

Follicular epithelial cell-derived thyroid tumors are common neoplasms comprised mainly of benign thyroid adenomas, follicular thyroid cancers, and papillary thyroid cancers (PTCs). Hypermethylation of the tumor suppressor gene RASSF1A and activating mutation of BRAF gene have been reported recently in thyroid cancers. To additionally investigate the roles of these two epigenetic/genetic alterations in thyroid...

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Source

Identifiers

PMID: 14996725
DOI: 10.1158/0008-5472.can-03-3242

Genes

BRAF
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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