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Selective killing of p53‐deficient cancer cells by SP600125

21 Mar 2012

Abstract excerpt

The genetic or functional inactivation of p53 is highly prevalent in human cancers. Using high-content videomicroscopy based on fluorescent TP53(+/+) and TP53(-/-) human colon carcinoma cells, we discovered that SP600125, a broad-spectrum serine/threonine kinase inhibitor, kills p53-deficient cells more efficiently than their p53-proficient counterparts, in vitro. Similar observations were obtained in vivo, in...

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PMID: 22438244
DOI: 10.1002/emmm.201200228

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