Article
Tumor susceptibility of Rassf1a knockout mice.
Cancer research - 1 Jan 2005
Tommasi Stella, Dammann Reinhard, Zhang Zhongqiu, Wang Yian, Liu Limin, Tsark Walter M, Wilczynski Sharon P, Li Jie, You Ming, Pfeifer Gerd P
Abstract excerpt
The human Ras association domain family 1 (RASSF1) gene is located at 3p21.3 in an area that is believed to harbor at least one important tumor suppressor gene. The two major isoforms of RASSF1, RASSF1A and RASSF1C, are distinguished by alternative NH(2)-terminal exons and the two transcripts initiate in two separate CpG islands. RASSF1A is one of the most frequently inactivated genes described thus far in human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.