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Article

The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models.

Mutation research - 6 Jan 2005

Attardi Laura D

Abstract excerpt

Genomic instability is a major force driving human cancer development. A cellular safeguard against such genetic destabilization, which can ensue from defects in telomere maintenance, DNA repair, and checkpoint function, is activation of the p53 tumor suppressor protein, which commonly responds to these DNA damage signals by inducing apoptosis. If, however, p53 becomes inactivated, as is typical of many tumors...

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Identifiers

PMID: 15603759
DOI: 10.1016/j.mrfmmm.2004.04.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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