Article
Mutations and aneuploidy: co-conspirators in cancer?
Cancer cell - 1 Aug 2003
Pihan German, Doxsey Stephen J
Abstract excerpt
The role of intragenic point mutations in human cancer is well established. However, the contribution of massive genomic changes collectively known as aneuploidy is less certain. Recent experimental work suggests that aneuploidy is required for sporadic carcinogenesis in mice and that it may coll...
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