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Article

Cell State Transitions and Phenotypic Heterogeneity in Luminal Breast Cancer Implicating MicroRNAs as Potential Regulators.

International journal of molecular sciences - 9 Feb 2023

Richard Vinitha, Nair Madhumathy G, Jaikumar Vishnu S, Jones Sara, Prabhu Jyothi S, Kerin Michael J

Abstract excerpt

Luminal breast cancer subtypes respond poorly to endocrine and trastuzumab treatments due to cellular heterogeneity arising from the phenotype transitions, accounted for mainly by the loss of receptor expression. The origins of basal-like and human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer subtypes have been attributed to genetic and protein modifications in stem-like cells and...

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Identifiers

PMID: 36834918
DOI: 10.3390/ijms24043497
PMCID: PMC9967449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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