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Article

The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells.

Breast cancer research and treatment - 1 Apr 2011

Vazquez-Martin Alejandro, Oliveras-Ferraros Cristina, Del Barco Sonia, Martin-Castillo Begoña, Menendez Javier A

Abstract excerpt

We here demonstrate that the anti-diabetic drug metformin interacts synergistically with the anti-HER2 monoclonal antibody trastuzumab (Tzb; Herceptin™) to eliminate stem/progenitor cell populations in HER2-gene-amplified breast carcinoma cells. When using the mammosphere culture technique, grade...

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Source

Identifiers

PMID: 20458531
DOI: 10.1007/s10549-010-0924-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20458531-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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