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Article

Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.

Blood - 4 Mar 2010

Pulikkan John A, Dengler Viola, Peramangalam Philomina S, Peer Zada Abdul A, Müller-Tidow Carsten, Bohlander Stefan K, Tenen Daniel G, Behre Gerhard

Abstract excerpt

Transcription factor CCAAT enhancer binding protein alpha (C/EBPalpha) is essential for granulopoiesis and its function is deregulated in leukemia. Inhibition of E2F1, the master regulator of cell-cycle progression, by C/EBPalpha is pivotal for granulopoiesis. Recent studies show microRNA-223 (miR-223), a transcriptional target of C/EBPalpha, as a critical player during granulopoiesis. In this report, we...

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Identifiers

PMID: 20029046
DOI: 10.1182/blood-2009-08-240101
PMCID: PMC2832809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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