Article
Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOEε4 carriers.
NeuroImage - 1 Feb 2011
Liang Winnie S, Chen Kewei, Lee Wendy, Sidhar Kunal, Corneveaux Jason J, Allen April N, Myers Amanda, Villa Stephen, Meechoovet Bessie, Pruzin Jeremy, Bandy Daniel, Fleisher Adam S, Langbaum Jessica B S, Huentelman Matthew J, Jensen Kendall, Dunckley Travis, Caselli Richard J, Kaib Susan, Reiman Eric M
Abstract excerpt
In a genome-wide association study (GWAS) of late-onset Alzheimer's disease (AD), we found an association between common haplotypes of the GAB2 gene and AD risk in carriers of the apolipoprotein E (APOE) ε4 allele, the major late-onset AD susceptibility gene. We previously proposed the use of fluorodeoxyglucose positron emission tomography (FDG-PET) measurements as a quantitative pre-symptomatic endophenotype,...
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