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Cerebral glucose uptake and cognitive functions: A phenome-wide Mendelian randomization study.

Journal of Alzheimer's disease : JAD - 1 Mar 2026

Ueda Masatoshi, Suzuki Takashi, Yoshimizu Toshiki, Konuma Takahiro, Maekawa Mariko, Sasase Tomohiko, Nishiu Jun

Abstract excerpt

BackgroundBased on both physiological perspectives and observational findings, increasing cerebral glucose uptake appears to be a novel therapeutic strategy to preserve cognitive function in patients with Alzheimer's disease (AD). However, the inherent limitations of observational studies make it difficult to establish clear causality.ObjectiveTo evaluate the potential of cerebral glucose uptake as a novel...

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PMID: 41758127
DOI: 10.1177/13872877261418310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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