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Article

Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Dec 2012

Jagust William J, Landau Susan M

Abstract excerpt

The ε4 allele of the polymorphic apolipoprotein E gene is associated with increased risk of Alzheimer's disease (AD), deposition of β-amyloid (Aβ), and reduction in cerebral glucose metabolism in asymptomatic people. Although ApoE4 may exert an effect on AD risk through amyloidogenic pathways, whether its effect on glucose metabolism is related to Aβ is unknown. To answer this question, we examined data from 175...

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Identifiers

PMID: 23238736
DOI: 10.1523/JNEUROSCI.3266-12.2012
PMCID: PMC3537830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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