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Article

Synergistic interaction between APOE and family history of Alzheimer's disease on cerebral amyloid deposition and glucose metabolism.

Alzheimer's research & therapy - 23 Aug 2018

Yi Dahyun, Lee Younghwa, Byun Min Soo, Lee Jun Ho, Ko Kang, Sohn Bo Kyung, Choe Young Min, Choi Hyo Jung, Baek Hyewon, Sohn Chul-Ho, Kim Yu Kyeong, Lee Dong Young

Abstract excerpt

BACKGROUND: Recently, the field of gene-gene or gene-environment interaction research appears to have gained growing interest, although it is seldom investigated in Alzheimer's disease (AD). Hence, the current study aims to investigate interaction effects of the key genetic and environmental risks-the apolipoprotein ε4 allele (APOE4) and family history of late-onset AD (FH)-on AD-related brain changes in...

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Source

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Identifiers

PMID: 30134963
DOI: 10.1186/s13195-018-0411-x
PMCID: PMC6106945

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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