Article

Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene

2023-05-23

Abstract excerpt

The insulin signaling pathway is evolutionarily conserved throughout metazoans, playing key roles in development, growth, and metabolism. Misregulation of this pathway is associated with a multitude of disease states including diabetes, cancer, and neurodegeneration. Genome-wide association studies indicate that natural variants in putative intronic regulatory elements of the human insulin receptor gene ( INSR) a...

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Literature Corpus work: 29d216af-4177-5427-b041-ae6ea3f23b6d
DOI: 10.1101/2023.05.23.541945

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