Article
A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2008
Kohyama-Koganeya Ayako, Kim Yeon-Jeong, Miura Masayuki, Hirabayashi Yoshio
Abstract excerpt
Glucose, one of the most important nutrients for animals, acts as a regulatory signal that controls the secretion of hormones, such as insulin, by endocrine tissues. However, how organisms respond to extracellular glucose and how glucose controls nutrient homeostasis remain unknown. Here, we show that a putative Drosophila melanogaster G protein-coupled receptor, previously identified as Bride of sevenless...
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