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Article

TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4.

Nature communications - 9 Jun 2021

Ou Qian, Fang Jia-Qi, Zhang Zhe-Sheng, Chi Zhe, Fang Jie, Xu Di-Yan, Lu Kai-Zhong, Qian Meng-Qing, Zhang Da-Yong, Guo Jun-Ping, Gao Wei, Zhang Na-Ru, Pan Jian-Ping

Abstract excerpt

TcpC is a multifunctional virulence factor of uropathogenic E. coli (UPEC). Neutrophil extracellular trap formation (NETosis) is a crucial anti-infection mechanism of neutrophils. Here we show the influence of TcpC on NETosis and related mechanisms. We show NETosis in the context of a pyelonephritis mouse model induced by TcpC-secreting wild-type E. coli CFT073 (CFT073wt) and LPS-induced in vitro NETosis with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34108482
DOI: 10.1038/s41467-021-23881-8
PMCID: PMC8190435

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