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Article

Notch pathway regulation of neural crest cell development in vivo

15 Dec 2011

Abstract excerpt

BACKGROUND: The function of Notch signaling in murine neural crest-derived cell lineages in vivo was examined. RESULTS: Conditional gain (Wnt1Cre;Rosa(Notch)) or loss (Wnt1Cre;RBP-J(f/f)) of Notch signaling in neural crest cells (NCCs) in vivo results in craniofacial, cardiac, and trunk abnormalities. Severe craniofacial malformations are apparent in Wnt1Cre;Rosa(Notch) embryos, while less severe skull...

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PMID: 22275227
DOI: 10.1002/dvdy.23717

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