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Article

N-acetyltransferase 2 polymorphisms and susceptibility to infant leukemia with maternal exposure to dipyrone during pregnancy.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2010

Zanrosso Crisiane Wais, Emerenciano Mariana, Gonçalves Bruno Alves de Aguiar, Faro Alessandra, Koifman Sérgio, Pombo-de-Oliveira Maria S

Abstract excerpt

BACKGROUND: Maternal exposure to dipyrone during pregnancy has been associated with risk of infant leukemia (IL). N-Acetyltransferase 2 (NAT2) enzyme acetylates dipyrone, resulting in a detoxified metabolite. We performed genotyping to identify the distribution of NAT2 polymorphisms in duo samples from mothers and children previously investigated in a case-controlled study of IL. METHODS: Samples from 132 IL, 131...

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Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20884738
DOI: 10.1158/1055-9965.EPI-10-0508

Genes

NAT2
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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