Article
Genetic polymorphisms of arylamine N-acetyltransferases 1 and 2 and the likelihood of developing pediatric acute lymphoblastic leukemia.
Leukemia & lymphoma - 1 Aug 2018
Hernández-González Oswaldo, Ortiz-Zamudio Juan José, Rodríguez-Pinal Cristian Jazmín, Alvarado-Morales Ildemar, Martínez-Jiménez Verónica Del Carmen, Salazar-González Raúl Alejandro, Correa-González Lourdes Cecilia, Gómez Rocío, Portales-Pérez Diana Patricia, Milán-Segovia Rosa Del Carmen
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is one of the main causes of death in children and is associated with both genetic susceptibility and environmental factors. Genes encoding the arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) isoenzymes are highly polymorphic among populations. Single-nucleotide polymorphism analysis was performed by real-time polymerase chain reaction from the genomic DNA of 225 healthy...
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