Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphisms of N-acetyltransferases 1 and 2 and gene-gene interaction in the susceptibility to childhood acute lymphoblastic leukemia.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2000

Krajinovic M, Richer C, Sinnett H, Labuda D, Sinnett D

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. In utero and postnatal exposures to various carcinogens may play a role in the etiology of this disease. N-acetyltransferases, encoded by the NAT1 and NAT2 genes are involved in the biotransformation of aromatic amines present in tobacco smoke, environment, and diet. Their rapid and slow acetylation activity alleles have been shown to modify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Environmental Exposure

Share to Odds Ratio

Share to Polymorphism, Genetic

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Risk Factors

Source

Identifiers

PMID: 10868688

Genes

NAT2
NAT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphisms of N-acetyltransferases 1 and 2 and gene-gene interaction in the susceptibility to childhood acute lymphoblastic leukemia.PMID 10868688Read ↗

N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Genetic susceptibility to childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Genetic polymorphisms of arylamine N-acetyltransferases 1 and 2 and the likelihood of developing pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Genetic variability in N-acetyltransferase 2 gene determines susceptibility to childhood lymphoid or myeloid leukemia in Brazil.Semantic proximity Read ↗

Relationship between NAT2 polymorphisms and onset risk of acute leukemia: a systematic review and meta-analysis.Semantic proximity Read ↗

Polymorphic NATs and cancer predisposition.Semantic proximity Read ↗

N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk.Semantic proximity Read ↗

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.Semantic proximity Read ↗

Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood LeukemiaSemantic proximity Read ↗

N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer.Semantic proximity Read ↗

Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome.Semantic proximity Read ↗

Polymorphisms of human N-acetyltransferases and cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.