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Article

Orofacial clefts and spina bifida: N-acetyltransferase phenotype, maternal smoking, and medication use.

Teratology - 1 Nov 2002

van Rooij Iris A L M, Groenen Pascal M W, van Drongelen Merel, Te Morsche René H M, Peters Wilbert H M, Steegers-Theunissen Régine P M

Abstract excerpt

BACKGROUND: Orofacial clefts and spina bifida are midline defects with a multifactorial etiology. Maternal smoking and medication use periconceptionally have been studied as risk factors for these malformations. The biotransformation enzyme N-acetyltransferase 2 (NAT2), plays a part in the inacti...

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Source

Identifiers

PMID: 12397635
DOI: 10.1002/tera.10096

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12397635-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Orofacial clefts and spina bifida: N-acetyltransferase phenotype, maternal smoking, and medication use.PMID 12397635Read ↗

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