Article
Placental expression of arylamine N-acetyltransferases: evidence for linkage disequilibrium between NAT1*10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NAT1 and NAT2.
Pharmacology & toxicology - 1 Oct 1998
Smelt V A, Mardon H J, Sim E
Abstract excerpt
The study of placental xenobiotic metabolism is important for the determination of foetal exposure to environmental chemicals as placental metabolism influences the nature of chemicals reaching the foetus from its mother's blood. Arylamine N-acetyltransferases are drug metabolizing enzymes which...
Topics
- Acetyltransferases
- Adult
- Alleles
- Arylamine N-Acetyltransferase
- Blotting, Western
- DNA
- Electrophoresis, Polyacrylamide Gel
- Female
- Fetus
- Gene Expression Regulation, Enzymologic
- Gene Frequency
- Haplotypes
- Humans
- Isoenzymes
- Linkage Disequilibrium
- Placenta
- Polymerase Chain Reaction
- Polymorphism, Genetic