Article
Acetylation of arylamines by the placenta.
European journal of drug metabolism and pharmacokinetics - 1 Jan 2000
Smelt V A, Mardon H J, Redman C W, Sim E
Abstract excerpt
The N-acetylation of arylamines and hydrazines used as drugs may alter their pharmacological or toxicological activity. Arylamine N-acetyltransferase (NATs) are involved in drug metabolism, as they catalyse the N-acetylation of arylamine and mono-substituted hydrazine substrates. Placental metabo...
Topics
- Acetylation
- Adult
- Amines
- Arylamine N-Acetyltransferase
- Blotting, Western
- DNA
- Erythrocytes
- Female
- Fetal Blood
- Genotype
- Humans
- In Vitro Techniques
- Placenta