Article
Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2.
Molecular biology of the cell - 15 Nov 2010
Penheiter Sumedha G, Singh Raman Deep, Repellin Claire E, Wilkes Mark C, Edens Maryanne, Howe Philip H, Pagano Richard E, Leof Edward B
Abstract excerpt
Transforming growth factor (TGF)-β family proteins form heteromeric complexes with transmembrane serine/threonine kinases referred to as type I and type II receptors. Ligand binding initiates a signaling cascade that generates a variety of cell type-specific phenotypes. Whereas numerous studies have investigated the regulatory activities controlling TGF-β signaling, there is relatively little information...
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