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Article

Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling.

Molecular and cellular biology - 1 Oct 2006

Hartung Anke, Bitton-Worms Keren, Rechtman Maya Mouler, Wenzel Valeska, Boergermann Jan H, Hassel Sylke, Henis Yoav I, Knaus Petra

Abstract excerpt

Endocytosis is important for a variety of functions in eukaryotic cells, including the regulation of signaling cascades via transmembrane receptors. The internalization of bone morphogenetic protein (BMP) receptor type I (BRI) and type II (BRII) and its relation to signaling were largely unexplored. Here, we demonstrate that both receptor types undergo constitutive endocytosis via clathrin-coated pits (CCPs) but...

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Identifiers

PMID: 16923969
DOI: 10.1128/MCB.00022-06
PMCID: PMC1636853

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