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Article

Constraints on HIV-1 diversity from protein structure.

Journal of virology - 1 Dec 2010

Woo Jeongmin, Robertson David L, Lovell Simon C

Abstract excerpt

The high rate of HIV-1 evolution contributes to immune escape, enables the virus to escape drug therapy, and may underlie the difficulty of producing an effective vaccine. Identifying constraints on HIV evolution is therefore of prime importance. To investigate this problem, we examined the relationships between sequence diversity, selection, and protein structure. We found that while there was an increase in...

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Share to env Gene Products, Human Immunodeficiency Virus
Share to Evolution, Molecular
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to Phylogeny

Share to Selection, Genetic

Share to Sequence Analysis, DNA

Source

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Identifiers

PMID: 20881050
DOI: 10.1128/JVI.00702-10
PMCID: PMC3004343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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